by skiersid2 » Mon Jan 26, 2009 2:02 pm
Cardiac Syndrome X (CSX) patients typically present with mainly effort induced angina and have normal coronary arteries per angiogram as well as lack of evidence or coronary artery spasm.
The main documentation to support evidence of myocardial ischemia for reimbursement in CSX patients will come from:
1. ST segment depression on 12-lead ECG during anginal episodes.
2. ST segment depression during exercise or pharmacological induced stress testing.
3. Transient myocardial perfusion abnormailities during radionuclide studies.
Some research has demonstrated metabolic evidence of stress induced myocardial ischemia in CSX patients by measuring transmyocardial lactate production, coronary oxygen saturation and pH reductions, and stress induced changes of high energy phosphate depletion during nuclear imaging.
Research has also demonstrated that endothelial dysfunction may play a role in CSX paients. Ultrasound testing of brachial artery dilitation to increased blood flow is thought to reflect a fair assessment of coronary endothelial function and abnormal flow-mediated dilitation in the brachial arteries has been associated with transient myocardial perfusion defects in patients with CSX.
C-reactive protein (CRP), an inflammatory marker, may also be elevated in CSX patients.
Hope this is helpful,
Cindy
Cindy Watts, RN, BSN, CET
Senior Clinical Application Specialist
Vasomedical, Inc.